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These products act during mitosis when chromosomes are split and begin to migrate along the tubules of the mitosis spindle towards one of its poles, before cell separation.

These substances are very similar but with somewhat varying toxicities and actions:

• vinblastine (Velban *)

• vincristine (Oncovin *),

• vindesine (Eldisine *)

• vinorelbine (Navelbine *).

Action mechanism of poisons of the cellular spindle. Under the action of such poisons, the spindle is disorganised with the dispersion of chromosomes during mitosis.

These molecules are highly active but should be administered strictly intravenously. Their major toxicity concerns blood count as well as the peripheral and intestinal nerves.