Ch 6 Example of Cancer Classification
Cancer
Classification
Corpus Uteri Cancer Classification

One of the most frequently used classifications is the classification by the Fédération Internationale de Gynécologie Obstétrique (FIGO) which has allowed comparisons between hospital series for more than 40 years.

The following drawings are available:

FIGO and TNM Classification

This classification requires surgery results and the study of surgical specimens to specify the invasion (when colpo-hysterectomy is feasible).

TNM

FIGO

Description

Tx   Primary tumour cannot be assessed
T0   No evidence of primary tumour
Tis St 0 Carcinoma in situ

T1

St I

Tumour limited to corpus uteri

  • tumour limited to endometrium
  • invasion of less than one half of the myometrium.
  • invasion greater than one half of the myometrium.

T2

St II

Invasion of cervix uteri

  • endocervical glandular involvement only.
  • cervical stromal invasion.

T3 and/or N1

St III

Tumour confined to the true pelvis

  • tumour invades serosa and/or adnexa and/or positive peritoneal cytology
  • vaginal metastases
  • metastases to pelvic and/or para-aortic lymph nodes
T4 St IVa Tumour invasion of bladder and/or bowel mucosa.

M1

St IV B

Distant metastases, including intra-abdominal and/or inguinal lymph nodes.

Non-operated patients

For non-operated patients, the classification is very similar. However for stage 2 cancers there are two classifications 2a for tumours situated in uteri within a small cavity (as observed on hysterography) and stage 2b for those situated within large uterine cavity.

Therapeutic results

According to FIGO publications: (Annual report on the results of treatment in gynaecological cancer. Twenty-first volume. Statements of results obtained in patients treated in 1982 to 1986, inclusive 3 and 5-year survival up to 1990. Int J Gynaecol Obstet. 1991 Sep;36 Suppl:1-315)

Stage 5 year survival
St 1
90 - 95 %
St 2
78 - 85 %
St 3
50 - 60 %
St 4
0 - 25 %

For French speaking readers, the website of the Lorraine oncology network, Oncolor describes the classification of endometrial adenocarcinoma as well as decision trees.

For English speaking readers, the NCI website is most valuable.

Another interesting website for pathology is Webpath from the University of Florida.

Cancer Classification - You are looking at www.oncoprof.net website